Antimicrobial nanocomposite coatings against catheter-associated urinary tract infections

2024年06月19日09:46 来源：无

Catheter-associated urinary tract infections (CAUTIs) pose a significant challenge in hospital settings. Current solutions available on the market involve incorporating antimicrobials and antiseptics into catheters. However, challenges such as uncontrolled release leading to undesirable toxicity, as well as the prevalence of antimicrobial resistance reduce the effectiveness of these solutions.

Research shows that a regenerative smart antimicrobial strategy combining bactericidal and releasing functions can be an effective measure against multidrug-resistant (MDR) bacterial infections. — A novel polymer nanocomposite coating gives urine catheters rapid antimicrobial and anti-biofilm properties. Giovanni Cancemi – stock.adobe.com

Additionally, conventional antibiotics fail to effectively eradicate entrenched bacteria and metabolically suppressed bacteria present in the biofilm, necessitating the exploration of alternative strategies. Here, the researchers introduce a novel polymer–nanocomposite coating that imparts rapid antimicrobial and anti-biofilm properties to coated urinary catheters. They have coated silicone-based urinary catheters with an organo-soluble antimicrobial polymer nanocomposite (APN), containing hydrophobic quaternized polyethylenei mine and zinc oxide nanoparticles, in a single step coating process. The coated surfaces exhibited rapid eradication of drug-resistant bacteria within 10–15 min, including E. coli, K. pneumoniae, MRSA, and S. epidermidis, as well as drug-resistant C. albicans fungi. APN coated catheters exhibited potent bactericidal activity against uropathogenic strains of E. coli, even when incubated in human urine.

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